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Academic Research Journal of
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Academic Research Journal of Agricultural Science and Research Vol. 3(7), pp. 173-177. July, 2015. ISSN: 2360-7874 DOI: 10.14662/ARJASR2015.025
Full Length Research The Effect of Ethanolic Extract of Cassia Fistula Leaves on Triton X100 Induced Hyperlipidemic Male Albino Rats
1Amaefule, K.I; *1Igwilo, I.O; 1Udedi, S.C; 2Obi, E and 3Igwilo, S.N
1Dept. of Applied Biochemistry, Nnamdi Azikiwe University, Awka, Nigeria. 2Dept. of Pharmacology and Therapeutics, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria 3Dept. of Human Kinetics and Health Education, Nnamdi Azikiwe University, Awka *Corresponding Author’s E-mail: igwilosaint@gmail.com
Accepted 2 June 2015
Hyperlipidemia is a disease condition characterized by the elevation of all lipid levels in the blood. It is an important risk factor in artherosclerosis which can lead to cardiovascular diseases (CVD). Cassia fistula linn (caesalpinaceae) tree is one of the most widespread in the forest of India, usually occurring in deciduous forests. The phytochemical determination of Cassia fistula plant revealed the presence of saponins, flavonoids, alkaloids and absence of phenols. Hyperlipidemia in rats was induced with Triton –X100 (a non –ionic detergent) which has been shown to elevate total cholesterol and triglyceride in the blood by altering hepatic lipid metabolism. Lipid profile of the hyperlipidemic control rats in this study showed higher levels of serum triglyceride, total cholesterol, low density lipoprotein followed by decrease in high density lipoprotein as compared to the normal control rats. Treatment of hyperlipidemic rats with low doses of astrovastatin (0.14mg/kg) showed a statistical difference (p< 0.05) in total cholesterol, triglycerides, very low density lipoprotein, low density lipoprotein (80.49± 10.00, 103±18.35, 20.68 ±3.56, 10.63±5.86 respectively) and increase in high density lipoprotein (49.24±2.92) compared to hyperlipidemic control while treatment with ethanolic extract of C. fistula at doses of 200mg/kg showed a reduction (91.41±27.88, 101.44±46.77, 20.16 ±9.14 and 23.48±18.73) in the levels of total cholesterol, triglycerides, very low density lipoprotein and low density lipoprotein respectively and increase in high density lipoprotein (48.30± 2.89). At 400mg/kg of the extract, the levels of total cholesterol, triglycerides, very low density lipoprotein, low density lipoprotein reduced to 82.09±12.89, 95.65±25.00, 19.12±5.00 and 14.05±10.41 respectively and increased the level of high density lipoprotein (48.92±1.93). At 600mg/kg the extract statistically reduced ( p< 0.05) total cholesterol, triglyceride, very low density lipoprotein and low density lipoprotein (77.87±14.18, 91.53±33.65, 18.27±6.70 and 9.04±5.69 respectively) and increased the level of high density lipoprotein to 50.54±3.17 compared to hyperlipidemic control. This study showed that ethanolic extracts of Cassia fistula exhibited hypolipidemic effect on Triton X100 induced hyperlipidemia.
Keywords: Cassia fistula leaves, Hyperlipidemia, Triton X100, Ethanolic extract.
How to cite this article: Amaefule KI, Igwilo IO, Udedi SC, Obi E, Igwilo SN (2015). The Effect of Ethanolic Extract of Cassia Fistula Leaves on Triton X100 Induced Hyperlipidemic Male Albino Rats. Acad. Res. J. Agri. Sci. Res. 3(7):173-177.
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